Microfluidics Corp.

Company Overview
Microfluidics, a division of MFIC Corp., pioneered the Microfluidizer high-pressure fluids processor, which delivers unique product capabilities, including unparalleled cell disruption rates, particle size reduction to nano-sized particles for dispersions, emulsions, liposomes and deagglomerations. Microfluidizer processors are used in research and development laboratories, as well as pilot and production manufacturing operations, where scale-up on your product is guaranteed. The Microfluidizer high shear processor technology is widely used in the pharmaceutical, biotechnology, digital ink, microelectronics, food, chemical and personal care industries.

Quick Facts
Microfluidics Corp.
30 Ossipee Road
Newton, Mass. 02464

Web:	www.microfluidicscorp.com
Email:	mixinginfo@mfics.com

Phone:	1 (617) 969-5452
Fax:	1 (617) 965-1213

Featured Solutions

• New intravenous drug therapies possible due to Microfluidizer processing by Microfluidics Corp.
  In this case study, Microfluidics Corp.'s Microfluidizer processor supports a Purdue University study involving intravenous delivery of drugs by supplying large quantities of very small lipid droplets whose uniform size can be reproduced from trial to trial.
  
  
• Helping cancer patients take their medicine by Microfluidics Corp.
  In this case study, a cancer treatment drug being tested in a trial at Johns Hopkins Oncology Center is delivered intravenously — with far fewer side effects for patients — with help from Microfluidics Corp.'s Microfluidizer processor.
  
  
• Genetic researchers score a bargain: Free delivery of DNA by Microfluidics Corp.
  In this case study, Microfluidics Corp. 's provides the University of Pittsburgh with a Microfluidizer processor that enables liposomes to carry DNA piggyback-style into a cell, a technique that speeds the regulatory approval process.
  
  
• Process optimization for making stable emulsions using accelerated dispersion... by Microfluidics Corp.
  In the search for the most effective emulsification parameters, multisample analytical centrifugation allows accelerated characterization of any demixing processes, in addition to quantification of time-dependent structural alterations without diluting the samples. This paper demonstrates the effectiveness of analytical centrifugation as a technique for fast emulsion stability measurements and homogenization parameter optimization.
  
  
• High shear fluid processing: More precise homogenization by Microfluidics Corp.
  This white paper by Microfluidics Corp. explains High Shear Fluid Processing method, which involves the creation of highly-controlled shear rates that are orders of magnitude greater than any other conventional means.
  
  
• Race is on to discover vaccine to save salmon by Microfluidics Corp.
  In this case study, Microtek International Ltd. uses Microfluidics Corp.'s M-110EH Microfluidizer processor, which extracts sterile proteins and maintains sterility throughout the cell disruption process, to help find a vaccine against a bacterium killing coho salmon.
  
  
• Microfluidizer processor helps increase the odds of drug discovery at Tularik by Microfluidics Corp.
  In this case study, Microfluidics Corp.'s Microfluidizer technology helps Tularik Inc. in its protein harvesting operation.
  
  
• Precision particle reduction enables new drug delivery methods by Microfluidics Corp.
  This white paper by Microfluidics Corp. explains precision particle reduction technology, which is critical to the efficacy and safety of a wide variety of drug delivery methods.
  
  
• Nano-Emulsion Formulations Improve Efficacy of Cancer Treatment by Microfluidics Corp.
  Nanoemulsions – formulations that encapsulate drug or nutrient molecules in sub-micron-sized oil droplets suspended in water – have been found to increase the rate and level of absorption into the body, and offer other benefits including the mitigation of side-effects as well as an antiviral and antibacterial action.
  
  
• Choosing The Best Cell Disruption Method for Research and Pharmaceutical ... by Microfluidics Corp.
  Microfluidics Corp. discusses cloning and culturing methods and the disruption of cells providing molecules of interest.
  
  
• Achieving optimal particle size distribution in inhalation therapy by Microfluidics Corp.
  This paper addresses the concerns that pharmaceutical manufacturers have when attempting to achieve the correct particle size and uniformity for a drug that is to be administered via an inhalation device, and how high-shear fluid processing can overcome those concerns.
  
  
• Next Generation Nanosuspension Processing for the Delivery of Non-Soluble Drugs by Microfluidics Corp.
  Roughly half of all new drugs in development are poorly soluble and often associated with low bioavailability. Among the most promising solutions to this challenge are nanosuspensions, defined as a colloidal dispersion of submicron pure drug particles that are stabilized by surfactants.
  
  
• Production of Polymer Nanosuspensions by Microfluidics Corp.
  <P>This article showcases polymer nanosuspensions in the range of 50-500 nm that were prepared with two different polymers, using both techniques. Furthermore, these tests indicate that an API was successfully encapsulated within the nanoparticles.</P>
  
  

• New multiple stream mixer reactor from Microfluidics Corp. by Microfluidics Corp.
  This application note by Microfluidics Corp. describes its Multiple Stream Mixer Reactor (MMR), a patented continuous mixer/reactor that pressurizes liquids and converts the pressurized energy to intense mixing in a proprietary mixing chamber.
  
  

• Fluid handling equipment: Microfluidizer materials processors, by ... by Microfluidics Corp.
  Microfluidics Corp.'s Microfluidizer processors provide the pharma and biopharma industries with high yields of undamaged proteins and nano-sized particles in dispersions, emulsions and injectables.
  
  
• M-110F Microfluidizer Processor by Microfluidics Corp.
  The M-110F Microfluidizer Processor provides high shear rates comparable to mixers and homogenizers on the market today, maximizing the energy-per-unit fluid volume to produce uniform submicron particle and droplet sizes.
  
  
• M-110L Microfluidizer Materials Processor by Microfluidics Corp.
  The M-110L Microfluidizer Materials Processor is a high shear fluid processing systems for lab-volume micro-emulsions, cell disruption, and micro-encapsualtion. The M-110L produces up to 18,000 psi with standard lab air.
  
  
• M-140K Microfluidizer Materials Processor by Microfluidics Corp.
  The M-140K is capable of processing a wide variety of fluids ranging from simple oil-in-water emulsions to highly abrasive solid-in-liquid suspensions.
  
  
• M-210EH Series Pilot Scale Microfluidizer Processors by Microfluidics Corp.
  The M-210EH Series A, B and C Microfluidizer Processors are pilot-scale machines that provide high shear rates, and are available to provide the user with a broad choice of operating pressures and product flow rates.
  
  
• M-700 Series Microfluidizer Materials Processor by Microfluidics Corp.
  M-700 Series Microfluidizer processors combine scaleable results for pilot and production environments.
  
  
• M-710 Microfluidizer Materials Processor by Microfluidics Corp.
  The new Model M-710 is a 100 HP high shear fluid processor capable of producing flow rates anywhere from 2 gpm (7.6 l/m) at 40,000 psi (2760 bar) to more than 15 GPM (57 l/m) at 5,000 psi (345 bar).
  
  
• Multiple Stream Mixer Reactor by Microfluidics Corp.
  The high-intensity Multiple Stream Mixer Reactor (MMR) is a patented continuous mixer/reactor that was designed to optimize the fast chemical reactions required in many of today’s chemical processes. It allows development and manufacture of nanomaterials in a process controlled to the molecular level of mixing.
  
  
• M-110S: Microfluidizer Materials Processor by Microfluidics Corp.
  The M-110S Microfluidizer small volume materials processor contains an air-powered intensifier pump designed to supply the desired pressure at a constant rate to the product stream.
  
  
• Data sheet: Microfluidizer M110-EH for E. Coli suspension by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which it was estimated that more than 95 percent cell disruption of an E. Coli suspension was achieved after one pass at 18,000 psi using an M110-EH Microfluidizer materials processor.
  
  
• Data sheet Microfluidizer M-110Y materials processor for lipid emulsion by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which the M-110Y Microfluidizer materials processor reduced the particle size of a lipid emulsion to a smaller mean than that of the Vortex mixer.
  
  
• Data sheet: Microfluidizer M110-EH materials processor for ophthalmic suspension by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which the particle size of an ophthalmic suspension were reduced to 0.7 μm in 35 passes at 25,000 psi using the M-110EH Microfluidizer materials processor.
  
  
• Data sheet: Microfluidizer M110-EH materials processor for yeast cell by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which more than 90 percent cell disruption of a yeast cell was achieved after five passes at 25,000 psi using the M-110EH Microfluidizer materials processor.
  
  
• Data sheet: Microfluidizer M-110Y materials processor for phthalocyanine blue... by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which 99 percent of particles of 5 percent phthalocyanine blue pigment dispersion were reduced to 0.43 μm in 40 passes at 21,000 psi using the M-110Y Microfluidizer materials processor.
  
  
• Data sheet: Microfluidizer M-110Ymaterials processor for drug slurry by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which the mean particle size of 25 percent drug slurry was reduced to less than 1μm in 10 passes at 18,000 psi using the M-110Y Microfluidizer materials processor.
  
  
• Data sheet: Microfluidizer M-210B materials processor for penicillin suspension by Microfluidics Corp.
  This materials processing data sheet from Microfluidics Corp. describes the results of a test in which the particle size of a penicillin suspension was reduced to 12μm after one pass at 18,000 psi using the M-210B Microfluidizer materials processor.
  
  
• M-110EH-30 microfluidizer processor by Microfluidics Corp.
  Microfluidics Corp.'s M-110EH-30 Microfluidizer is recommended for particle size reduction for submicron and nano-sized particles, deagglomeration, cell disruption, immiscible liquid emulsions, solid-in-liquid suspensions, and liposomes.