Thermo Electron Corp.

Company Overview

Thermo Electron Corp. develops and manufactures laboratory, analytical, measurement and control instruments and software. For pharmaceutical companies, Thermo Electron provides research and development capabilities such as chromatography, elemental analysis, electrochemistry, mass spectrometry, microanalysis, molecular biology and sample preparation. In addition, the company offers production capabilities such as controlled environment, laboratory automation, materials characterization, pharmaceutical extrusion and process instruments.

Darwin laboratory information management system (LIMS) software is specifically designed to address the needs of pharmaceutical manufacturing research and development and quality assurance/quality control labs. Darwin's batch- and product-oriented design aligns directly with manufacturing processes, allowing R&D and production data to be logically organized, summarized and reported. The system handles single- and multi-point dissolution; content uniformity; product, stability and batch management; and system interfacing.

Quick Facts
Thermo Electron Corp.
81 Wyman St.
Waltham, MA 02454

Featured Solutions

• Process analytical technology: A framework for innovative pharmaceutical ... by Thermo Electron Corp.
  In this white paper, Thermo Electron Corp. provides its perspective on the impact of process analytical technology (PAT) on pharmaceutical manufacturers and their vendors.
  
  
• A guide to raw material analysis using fourier transform near-infrared ... by Thermo Electron Corp.
  This white paper by Thermo Electron Corp. discusses the principles behind the planning, development and implementation of Fourier transform near-infrared (FT-NIR) spectroscopic libraries for raw material identification and qualification and the steps in establishing a raw material program.
  
  
• Cryopreservation manual: A guide to cryoprotective technique by Thermo Electron Corp.
  This white paper by Thermo Electron Corp. is a manual on cryopreservation techniques.
  
  
• Importance of Class 100 air in a CO2 incubator by Thermo Electron Corp.
  This white paper by Thermo Electron Corp. describes the development of the HEPA (high efficiency particulate air) filter method designed to handle the primary sources of contamination found in most laboratory settings, and explains the benefits of Thermo Electron's Thermo HEPA.
  
  
• Effective heat sterilization in CO2 incubators by Thermo Electron Corp.
  This white paper by Thermo Electron Corp. describes the heat sterilization cycle, which eliminates vegetative microorganisms and persistent fungal spores.
  
  
• Forma lab refrigerators-freezers provide advanced refrigeration systems to ... by Thermo Electron Corp.
  This white paper explains how Thermo Electron Corp.'s lab refrigerators and freezers meet the needs of the laboratory environment.
  
  
• Basics of centrifugation by Thermo Electron Corp.
  This white paper, written before Kendro Laboratory Products was acquired by Thermo Electron Corp., explains the basics of centrifugation.
  
  

• Analysis of capsule contents by Fourier transform near-infrared spectroscopy by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. investigates the effectiveness of Fourier transform near-infrared (FT-NIR) spectroscopy as a means for qualitative and quantitative analysis of conventional hard gelatin capsules in sampling options and capsule analysis.
  
  
• CLS method to compensate for FT-NIR spectral features by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes a quantitative analysis technique that provides a simple way to augment a classical least squares (CLS) with a principal component regression method to compensate for spectral variance not accounted for in the original standards.
  
  
• Diffuse reflectance Fourier transform near-infrared spectroscopy to confirm ... by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. investigates diffuse reflectance Fourier transform near-infrared (FT-NIR) spectroscopy as a tool to monitor the integrity of production blending processes.
  
  
• Performance of the integrating sphere module on the antaris FT-NIR analyzer by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes a series of tests performed on the Antaris solid sampling system to verify key performance features important in a number of reflectance applications.
  
  
• Quantitative characterization of lactose crystalline forms by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes how FT-NIR spectroscopy is an excellent candidate for use as a routine tool in quantitative characterization of lactose crystalline forms.
  
  
• Method transfer through superior engineering by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes the effect of replacing the laser and source on the reproducibility of spectral data and the change in peak locations after replacing the laser and source.
  
  
• Near-infrared analysis of critical parameters in lyophilized materials by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. demonstrates the performance of the Nicolet Antaris FT-NIR spectrometer in analyzing lyophilized samples of thrombin, a topical coagulant.
  
  
• Dedicated analytical solutions for tablets and softgels by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes how Fourier transform near-infrared (FT-NIR) analysis is a powerful technique for measuring tablets and softgels.
  
  
• Study of NIR model transferability using binary mixtures of talc by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes model transferability using binary mixtures of talc in iron sulfate and water in ethanol, and how these applications can assess the transferability of quantitative models between multiple Nicolet Antaris Fourier transform near-infrared (FT-NIR) instruments.
  
  
• Measurement of samples by transmission spectroscopy by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes how near-infrared (NIR) spectroscopy has significant fundamental advantages that allow the use of transmission for solid samples such as polymers and pharmaceutical formulations.
  
  
• Two case studies of the transfer of near-infrared methods for the analysis of... by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes the ability to transfer calibration methods from a primary Fourier transform near-infrared (FT-NIR) instrument to a target instrument, which is assessed using two sets of tablets with varying physical characteristics.
  
  
• Verification of wavelength accuracy in an FT-NIR spectrometer by Thermo Electron Corp.
  In this application note, Thermo Electron Corp. describes the wavelength stability of the Nicolet Antaris Fourier transform near-infrared (FT-NIR) spectrometer over time and explains how to evaluate the wavelength accuracy between several systems. It also outlines how the effects of resolution and beam path optics on line shapes were evaluated.