Malvern Instruments Ltd.

Company Overview
Malvern Instruments Ltd. provides on-line, at-line and off-line analytical solutions for particle sizing and characterization using laser diffraction, image analysis, laser doppler micro electrophoresis, static and dynamic light scattering, and stress- and strain-controlled rheometry. These techniques enable size analysis from the molecular scale to millimeter-sized granules. The process analytical technologies (PAT) initiative of the U.S. Food and Drug Administration requires the retrieval of real-time data, such as the tracking of particle size and size distribution changes, while the process is running. Malvern Instrument’s on-line particle characterization systems allow manufacturers to follow pharmaceutical milling, classification, spray drying and granulation processes, yielding closed-loop process control and improved production efficiency and product quality.

Quick Facts
Malvern Instruments Ltd.
10 Southville Road
Southborough, MA 01772

Featured Solutions

• Measuring Sub-Nanometer Sizes Using Dynamic Light Scattering by Malvern Instruments Ltd.
  This paper by Malvern Instruments discusses the factors which will influence the lower size limit of dynamic light scattering (DLS) and reports the use of sucrose as a test sample to probe this lower limit of the technique.
  
  

• Automated protein characterization by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes automated measurements that can be made by coupling its Nano system with its MPT-2 titrator. It also examines the effects of pH on the size and charge of a typical protein with data collected using the titrator.
  
  
• Method validation for laser diffraction measurements by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes the need for method validation for and outlines some of the important variables that should be assessed when considering the precision of laser diffraction measurements.
  
  
• Characterization of mixed micelles by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes the Zetasizer Nano ZS, which is used to measure micelle size for the TX-100/SDS, the most studied nonionic/anionic micelle system, at a variety of ionic strengths and surfactant compositions.
  
  
• Optimizing topical skin care formulations and production by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes how manufacturing process variables can be optimized by studying variations that occur in either, or both, the particle size and zeta potential of a commercially available raw material used in skin care product formulation and manufacture.
  
  
• Characterization of polymers using light scattering techniques by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes how its Zetasizer Nano series with NIBS optics allows for the study of small, weakly scattering particles such as polymers at low concentrations and offers easy setup of temperature versus size and intensity measurements.
  
  
• Automated size and intensity trend measurements by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes its Zetasizer Nano range, which has the capability of automating the measurement of particle size and scattering intensity as a function of temperature or time, and discusses trend measurements options with application examples.
  
  
• Ultrasonic spectroscopy for particle size analysis of concentrated systems by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd. describes its Ultrasizer, which provides a convenient method for monitoring flocculation and coalescence in concentrated systems such as emulsions without dilution.
  
  
• Rapid refractive index determination for pharmaceutical actives: Application ... by Malvern Instruments Ltd.
  In this application note, Malvern Instruments Ltd outlines the procedure for determination of refractive index (RI) for powdered materials using simple refractometer measurements.
  
  
• Set Up Classifications Using the Morphologi G3’s Scattergram Tool by Malvern Instruments Ltd.
  This application note will demonstrate how the Malvern scattergram can be used to visualize data and set up classifications.
  
  

• Particle sizers: On-line, by Malvern Process Systems by Malvern Instruments Ltd.
  Malvern Instruments Ltd. provides on-line, at-line and off-line analytical solutions for particle sizing and characterization.
  
  
• On-line Particle Sizers by Malvern Instruments Ltd.
  For particulate processing, the Malvern Instruments range of on-line particle sizing systems delivers high quality information necessary for effective decision making and control.