GE Analytical Instruments

Company Overview

GE Analytical Instruments, a division of GE Water & Process Technologies, manufactures the world's most sensitive, selective and robust scientific instruments and is the leading provider of Total Organic Carbon Analyzers to the pharmaceutical industry. Pharmaceutical and biopharmaceutical companies worldwide rely upon the Sievers brand of TOC analyzers for monitoring pharmaceutical waters for USP, EP and JP compliance in lab and process environments, and for process analytical technology (PAT) and other quality initiatives such as on-line compendial water release and cleaning validation.

Sievers TOC Analyzers are based on patented membrane conductometric detection technology and are known for their superior analytical performance, high automation and ease of use. New models include the reagentless 500 RL On-Line TOC Analyzer and the application-specific 900 Series (Portable, Laboratory and On-Line).

Other pharmaceutical industry products include the new battery-powered CheckPoint Portable/On-Line TOC Sensor, the Cleaning Validation Support Package (CVSP), Sievers TOC Standards, and Sievers Certified (<10 ppb)TOC Vials.

Quick Facts
GE Analytical Instruments
6060 Spine Road
Boulder, CO 80301

Web:	www.geinstruments.com
Email:	geai@ge.com

Phone:	1 (303) 444-2009 / 800-255-6964
Fax:	1 (303) 444-9453

Featured Solutions

• A science-based performance comparison of on-line TOC analyzers by GE Analytical Instruments
  This white paper by GE Analytical Instruments describes performance capabilities of on-line TOC analyzers in the production of purified water.
  
  
• Deciphering VVQ — How validation, verification and qualification affect TOC ... by GE Analytical Instruments
  This paper is intended to demonstrate what mode (validation, verification, or qualification) of choice should be used for TOC instrumentation or the methodology.
  
  
• The right analytical method for the right application: TOC analysis for ... by GE Analytical Instruments
  This paper investigates the advantages of using a non-specific method, TOC analysis, for cleaning validation and shows how using Sievers TOC technology can improve yields, equipment uptime, and the plant's bottom line.
  
  

• Quality control of TOC measurements by GE Analytical Instruments
  This application note by GE Analytical Instruments offers insights into the use of its total organic carbon (TOC) analyzers including calibration, verification, system suitability and the use of laboratory control samples.
  
  
• Taking the mystery out of maximum allowable carryover (MAC) calculations for ... by GE Analytical Instruments
  This application note by GE Analytical Instruments presents a step-by-step understanding specific for establishing acceptance criteria limits for cleaning with the use of total organic carbon (TOC).
  
  
• Validating the TOC method for cleaning validation applications in the ... by GE Analytical Instruments
  This application note by GE Analytical Instruments provides examples of parameters as they relate to total organic carbon (TOC) method validation, including detection and quantitation limits.
  
  
• PAT application: At-line TOC for cleaning validation and product changeover by GE Analytical Instruments
  This application note from GE Analytical Instruments demonstrates the applicability and capability of at-line total organic carbon (TOC) analysis for periodic swab sampling for cleaning validation and applying the same practices for product changeover using the Sievers 900 Portable TOC Analyzer.
  
  
• Comparison of TOC Analyzers and Sensors for Pharmaceutical TOC Applications by GE Analytical Instruments
  In 2006, Jon S. Kauffman, PhD., Lancaster Laboratories, published results from a study on the recovery of organic compounds likely to be present in pharmaceutical water systems using on-line TOC analyzers designed for pharmaceutical use. A new study repeats the same injections, but adds the new CheckPoint TOC Sensor from GE Analytical Instruments.