Shimadzu Scientific Instruments

Company Overview
Shimadzu Scientific Instruments (SSI) is the American subsidiary of Shimadzu Corporation, headquartered in Kyoto, Japan. Founded in 1875, Shimadzu encompasses three major divisions: Medical Diagnostics, Aerospace/Industrial, and Analytical Instruments. The Analytical Instruments Division is one of the world's largest manufacturers of analytical instrumentation and environmental monitoring equipment.

Balancing the needs of QA/QC and speed to market can be an intricate process and requires a diverse range of products to ensure success and regulatory compliance. From discovery to research on new drug candidates to method development and ensuring ultra-pure water, Shimadzu can accelerate your process with a full lineup of analytical and life science instruments. Backed by the most advanced software available, fully compliant with 21 CFR Part 11 and other regulations, you’ll have complete confidence as you seek to unravel the mysteries of science.

Our full range of products includes chromatographs (HPLC/UFLC, GC), mass spectrometers (LC/MS, GC/MS, MALDI), spectrophotometers (UV-VIS-NIR, FT-IR, Fluorescence), atomic spectrometry (ICP, AA), Total Organic Carbon (TOC) analyzers, balances, particle size analyzers, thermal analyzers, and materials testers..

Quick Facts
Shimadzu Scientific Instruments
7102 Riverwood Drive
Columbia, MD 21046

Web:	www.ssi.shimadzu.com
Email:	kgmclaughlin@shimadzu.com

Phone:	(800) 477-1227 or +1 (410) 381-1227
Fax:	(410) 381-1222

Featured Solutions

• Analysis of basic drugs by column-switching liquid chromatography-mass ... by Shimadzu Scientific Instruments
  This white paper describes the analysis of tricyclic antidepressants (doxepin, desipramine, imipramine, nortriptyline, amitriptyline and clomipramine) by LC/MS using the MC-SCX.
  
  
• Clarification of Various Misconceptions About Total Organic Carbon Analysis by Shimadzu Scientific Instruments
  TOC can be determined in pharmaceutical water or other types of water samples using either the Difference or the Acidify & Sparge methods. This white paper examines both methods for TOC analysis and dissolves certain misconceptions plaguing both
  
  
• Measuring samples per USP 26 using Shimadzu TOC-VW by Shimadzu Scientific Instruments
  The TOC-VW analyzer utilizes three forms of oxidation (heat, UV, and persulfate) to provide a low maintenance instrument with a detection limit of 0.0005 mg per liter.
  
  
• High sensitivity MS determination of carryover in a new autosampler design by Shimadzu Scientific Instruments
  This white paper offers preventative methods to reduce sample carryovers in pharmaceutical applications.
  
  
• USP acceptable TOC levels for pharmaceutical water: How to achieve them? by Shimadzu Scientific Instruments
  This white paper attempts to classify compliance with acceptable TOC levels in pharmaceutical water regulations through preparation, production and waste discharge.
  
  
• Detecting compounds of dissimilar ionization using dual source ionization for... by Shimadzu Scientific Instruments
  By combining electrospray and atmospheric pressure chemical ionization into a single run, instrument time can be halved, allowing for a greater number of samples to be analyzed
  
  
• MSn analysis of natural nutraceutical supplements by Shimadzu Scientific Instruments
  In this white paper, Shimadzu investigates the use of MALDI-QIT- TOF-MS in the identification and structural elucidation of biologically active ingredients in red fruit/vegetables, green-tea and ginseng; comparing and contrasting these results with those obtained using ESI-IT-TOF-MS.
  
  
• How new advances in FTIR sampling technology can make your life easier by Shimadzu Scientific Instruments
  FTIR has become a more useful tool in the past 20-25 years. This white paper the evolution of Attenuated Total Reflectance (ATR) as a significant development for FITR.
  
  
• USP Acceptable TOC Levels for Pharmaceutical Water: How to Achieve Them? by Shimadzu Scientific Instruments
  Several specific and non-specific analytical techniques exist that may help the industry monitor the pharmaceutical water used and also help achieve the required cleaning validation.
  
  
• Evaluation of precision with ultra-fast LC conditions by Shimadzu Scientific Instruments
  There is a growing trend toward the use of smaller particle size columns to reduce analysis time and increase sample throughput. This paper describes a new 2.2 µm particle size column which, when used in an LC system with high-resolution pumps and a high-speed autosampler, yields higher throughput with back-pressures similar to traditional HPLC conditions.
  
  
• Fact or Fiction: Automated dissolution testing reduces operator error and ... by Shimadzu Scientific Instruments
  The studies discussed in this white paper showed that whereas automated dissolution testing did not improve the accuracy or precision of the test results, it did boost overall efficiency (in that it reduced the time required for analysis).
  
  
• An Evaluation of Fourier Transform Infrared (FTIR) Microscopy: Packaging, ... by Shimadzu Scientific Instruments
  In this paper by Shimadzu Scientific Instruments, the usefulness of FTIR microscopy to a pharmaceutical scientist is evaluated.
  
  
• Achieving Ultra Fast Liquid Chromatography by Shimadzu Scientific Instruments
  The demand for increased efficiency and speed in pharmaceutical analysis extends through drug discovery and development to clinical screening and trials. The need to meet these throughput requirements without compromising the data has highlighted the important technical challenge of providing faster separation in HPLC.
  
  

• An evaluation of fourier transform infrared (FTIR) microscopy: packaging, ... by Shimadzu Scientific Instruments
  FTIR Microscopy fits this niche by performing routine analysis on tablets, caplets, and packaging materials in the pharmaceutical industry. This application note will evaluate the utility that each of these techniques can provide to a pharmaceutical scientist.
  
  
• Achieving ultra fast liquid chromatography (UFLC) by Shimadzu Scientific Instruments
  This paper describes various approaches to achieving faster separation and explains how combining Shimadzu's Prominence UFLC components with XR-ODS columns enables users to shorten analysis time dramatically.
  
  
• Analysis of amoxicillin by Shimadzu Scientific Instruments
  In this application note, Shimadzu Scientific Instruments describes the analysis of amoxicillin using its LCMS-2010EV and the LCMS-IT-TOF analysis.
  
  
• High-accuracy measurement of TOC below 5 ppb levels by Shimadzu Scientific Instruments
  This application note demonstrates how Shimadzu's TOC-VW instrument meets current regulatory demands of ultrapure applications by achieving practical quantitation below 5 ppb.
  
  
• Comparison of headspace GC sensitivity depending on dilution solvents (Class ... by Shimadzu Scientific Instruments
  This application note details a study in which Class 3 solvents — water, DMSO and DMF — were analyzed by headspace GC using DMI as the dilution solvent. Researchers found that there were no components that could achieve a particularly good sensitivity when using DMI, compared to when using other dilution solvents.
  
  
• The determination of drug composition and manufacturer by Shimadzu Scientific Instruments
  In this application note, Shimadzu Scientific Instruments describes how to determine the composition and manufacturer of a drug using Fourier transform infrared (FTIR) chromatography analysis, and results of a study on enteric-coated aspirin tablets to determine if it is possible to differentiate among manufacturers and identify the manufacturer of a particular tablet.
  
  

• Balances: AU, UW/UX, by Shimadzu Scientific Instruments by Shimadzu Scientific Instruments
  Shimadzu balances and scales offer features such as temperature-activated calibration, OIML and NIST-traceable standards and high-speed analysis. Products include analytical and micro-balances, top loading balances, precision platform scales and moisture balances.
  
  
• UW/UX Series Automatic Calibration Balances by Shimadzu Scientific Instruments
  Shimadzu Scientific Instrument's new Uniblock technology is used in their high-precision balances which can be used for a wide-range of applications.
  
  
• AUW-D/AUW/AUX/AUY UniBloc Analytical Balances by Shimadzu Scientific Instruments
  Shimadzu Scientific Instrument's AUW-D dual range five-decimal balances measure in compliance with GLP/GMP/ISO9000 and offer an automatic span calibration.