Grace Davison Discovery Sciences

Company Overview
Grace Davison Discovery Sciences, formerly Grace Vydac, provides high-pressure liquid chromatography (HPLC) columns and separation products. We are proud of our accomplishments including developing benchmark HPLC silica for the separation of polypeptides. Grace Davison Discovery Sciences now offers polymer and silica-based materials in packed columns including capillary columns for liquid chromatography/mass spectrometry (LC/MS) and bulk media. Our commitment is shown by a continuing effort to provide the most reproducible products possible, and to development of new products to meet current and future separation needs. We are an ISO 9001 certified company.

Quick Facts
Grace Davison Discovery Sciences
2051 Waukegan Road
Deerfield, IL 60015

Web:	www.discoverysciences.com
Email:	contact.alltech@grace.com

Phone:	(847) 948-8600
Fax:	(847) 948-1078

Featured Solutions

• USP-compliant separations of multi-ring pharmaceuticals by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, describes multiple-ring structures in pharmaceuticals that are best separated by wide-pore, reversed-phase chromatography, and how its 218MR columns are designed for such separations and assure performance in compliance with U.S. Pharmacopeia standards.
  
  
• Ultra high resolution reversed-phase columns and media by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, describes its Everest high-pressure liquid chromatography (HPLC) columns, which use a silica treatment that provides improved bonding and peptide recoveries helpful for peptide mapping, purification of synthetic peptides and high-peptide-load runs.
  
  
• Optimizing peptide purifications by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, shows separations of the same synthetic peptide mixture on two different reversed-phase columns under identical conditions of flow, temperature and organic solvent gradient. The separations show that wide-pore packings provide the best reversed phase separations, among other results.
  
  
• What is 0.1 percent TFA? by Grace Davison Discovery Sciences
  In this application note by Grace Vydac, now Grace Davison Discovery Sciences, the importance of trifluoroacetic acid (TFA) concentration for peptide selectivity in chromatographic applications is explained.
  
  
• Fast protein and peptide analyses with Vydac 3µm 300A reversed-phase columns by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, discusses its 3µm 300A reversed-phase columns, which make rapid analysis possible and are ideal for in-process testing, combinatorial library screening, screening of recombinant clones and studies of reaction kinetics.
  
  
• Process scale-up of protein and polypeptide separations by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, discusses a time- and material-saving procedure that allows near-optimum conditions for process chromatography. It is also suitable for ion-exchange chromatography.
  
  
• Reversed-phase preparative and process chromatography by Grace Davison Discovery Sciences
  In this application note, Grace Vydac, now Grace Davison Discovery Sciences, demonstrates the power of reversed-phase preparative and process chromatography for protein purification.
  
  
• Small molecule separations and fast LC on 90 Å and 300 Å reversed-phase columns by Grace Davison Discovery Sciences
  In this application note, Grace Vydac, now Grace Davison Discovery Sciences, discusses the benefits of Vydac 300 Å columns for small-molecule high-pressure liquid chromatography (HPLC) applications.
  
  
• The concept of a resolution mixture in developing and validating process ... by Grace Davison Discovery Sciences
  In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, discusses the concept of a resolution mixture, which can be used early in method development to screen parameters such as solvent, buffer and pH, column type and manufacturer in order to optimize the preparative separation.