Ultrasonics beats optical methods for measuring some critical attributes

High-resolution ultrasonic spectroscopy (HR-US) can be a powerful tool in developing new products and optimizing existing ones, as well as for quality control in an installation of process analytical technology (PAT). HR-US provides real-time information on chemical and microstructural characteristics for a wide range of materials and processes. In this white paper, Ultrasonic Scientific describes features of HR-US that are beneficial for PAT and provides applications, including real-time monitoring of the sedimentation and particle size evolution in drug suspensions, and the effect of drug coating and drug concentration on these processes.

High-resolution ultrasonic spectroscopy (HR-US) is based on precision measurements of the parameters of non-destructive acoustical waves propagating through materials. This allows fast at/online analysis of formulation consistency of raw materials, ingredients and intermediates, as well as process impurity analysis, particle sizing, batch-to-batch variation, stability assessment and more. HR-US has the advantages of no sample preparation, no moving parts, no minimum calibration and no consumables needed.

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