Preformulation Technical Notes: API Solubility Enhancement
by Cardinal Health
This white paper by CardinalHealth explains systematic approach for investigation of solubility behavior of active pharmaceutical ingredient (API). A recommended systematic approach is described in this paper, starting with full profiling of neat API followed by development of suitable dosing vehicles for preclinical studies. This approach can lead to simple dosage forms that can be easily progressed to Phase 1 clinical dosage forms such as solutions, suspensions or “powder-in-a-bottle.”
| Published: | 2006 |
| Format: | |
| Length: | 1 page |
| Type: | White paper |
| Language: | English |
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