Enantioseparation through supercritical fluid simulated moving bed (SF-SMB) chromatography
by Novasep Inc.
This white paper by Novasep Inc. discusses enantioseparation in a supercritical fluid simulated moving bed (SF-SMB) unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions. Complete separation of the two enantiomers of tetralol is achieved both in the pressure-gradient mode, where a pressure gradient is imposed along the four sections of the unit, and in the isocratic mode, where the pressure is kept constant. However, an almost threefold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. Results are explained and rationalized using recently developed design criteria for SMBs, the so-called “triangle theory,” which have been properly extended to allow for different pressure values in the different sections of the unit.
| Published: | 2001 |
| Format: | |
| Length: | 7 pages |
| Type: | White paper |
| Language: | English |
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