Comparison of headspace GC sensitivity depending on dilution solvents (Class 3 Solvents)
by Shimadzu Scientific Instruments
There are two methods of analyzing residual solvents in pharmaceuticals: a method where the pharmaceutical is dissolved in a solvent and the solution is directly injected to a gas chromatograph (GC), and a method where the solution is enclosed and heated in a vial and the evaporated gas phase is analyzed by GC. The latter method is called the headspace GC.
This application note details a study in which Class 3 solvents — water, DMSO and DMF — were analyzed by headspace GC using DMI as the dilution solvent. Researchers found that there were no components that could achieve a particularly good sensitivity when using DMI, compared to when using other dilution solvents.
This application note details a study in which Class 3 solvents — water, DMSO and DMF — were analyzed by headspace GC using DMI as the dilution solvent. Researchers found that there were no components that could achieve a particularly good sensitivity when using DMI, compared to when using other dilution solvents.
| Published: | 2007 |
| Format: | |
| Length: | 2 pages |
| Type: | Application Note |
| Language: | English |
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