Laboratory
FEATURED REPORTS
WHAT'S NEW
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Leveraging IT to transform drug discovery
by Infosys Technologies Ltd.
White paper
This white paper by Infosys Technologies Ltd. describes how a hypothetical plasma therapeutics company leveraged information technology to reduce drug development costs.
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Multiple mini-format 2-D electrophoresis
by GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes two-dimensional electrophoresis, a powerful analytical technique to resolve thousands of individual proteins in complex biological samples. The method provides convenience and reproducibility of precast gels for the first and second dimensions.
REPORTS BY SUBTOPIC
CHO cell culture application using a BioFlo 110 benchtop bioreactor
By New Brunswick Scientific Co.
Application note
In this application note, New Brunswick Scientific Co. discusses simple protocols for culturing cells in a BioFlo 110 benchtop fermentor/bioreactor system and concentrates on achieving high-density CHO cell cultures using its Advanced Cell Culture Kit.
Multiple mini-format 2-D electrophoresis
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes two-dimensional electrophoresis, a powerful analytical technique to resolve thousands of individual proteins in complex biological samples. The method provides convenience and reproducibility of precast gels for the first and second dimensions.
Detecting intracellular cytokines in activated monocytes
By BD Biosciences
Application note
In this application note, BD Biosciences describes methods of detecting intracellular cytokines in activated monocytes.
Leveraging IT to transform drug discovery
By Infosys Technologies Ltd.
White paper
This white paper by Infosys Technologies Ltd. describes how a hypothetical plasma therapeutics company leveraged information technology to reduce drug development costs.
Determining monoclonal antibody specificity using the Guava CellPaint assay
By Guava Technologies Inc.
Application note
In this application note, Guava Technologies, Inc. describes its CellPaint assay for determining monoclonal antibody specificity.
Measuring Chemokine-Induced Chemotaxis through Actin Polymerization Assays
By Guava Technologies Inc.
Application note
In this application note, Guava Technologies, Inc. explains measuring of Chemokine-induced Chemotaxis through actin polymerization assays.
Screening compounds for Apoptotic and Cytotoxic activity
By Guava Technologies Inc.
Application note
In this application note, Guava Technologies, Inc. demonstrates the usefulness and reproducibility of plate based cellular assays to screen for small molecules with cytotoxic and apoptotic activity.
Performance characteristics of the Yeast ProtoArray PPI Proteome microarray
By Invitrogen Corp.
White paper
This white paper by Invitrogen Life Technologies describes a new paradigm for studying protein interactions on a proteome scale, the Yeast ProtoArray PPI Proteome microarray.
AAIPharma Services Offerings
By AAI Pharma Inc.
Product literature
AAIPharma is a provider of product development and support services to the pharmaceutical, biotechnology, and medical device industries. They offer a range of services including analytical, bioanalytical, clinical, and pharmaceutical services.
Automated identification and sequencing of post-translational modifications ...
Application note
In this application note, MDS Sciex describes an automated workflow to identify post-translational modifications (PTMs) and determine the site of modification.
Clinical Supply Services
By Cardinal Health
Product collateral
Services include primary packaging, secondary packaging, package engineering and design, labeling and assembly, stability packaging, supply chain management, material logistics, and analytical support.
High Performance Capillary Electrophoresis of Carbohydrates
By Beckman Coulter Inc.
White paper
This white paper by Beckman Coulter Inc. describes the basic aspects of the electrolyte systems used in high performance capillary electrophoresis (HPCE) of carbohydrates, to discuss the advantages and disadvantages of the approaches and concepts that are most useful in the separation and detection of carbohydrates by HPCE, and to review important applications for various types of carbohydrates.
There are currently no reports available for this topic.
Closed-loop, steady-state recycling—a powerful chromatographic tool for ...
By Novasep Inc.
White paper
This white paper by Novasep Inc. examines a chiral separation in which there is lack of resolution between the two components. Using laboratory test data and simulation study results, it demonstrates how closed-loop, steady-state recycling was used with high-pressure liquid chromatography (HPLC) to improve productivity.
SMB emerges as chiral technique
By Novasep Inc.
White paper
This white paper by Novasep Inc. describes advantages of the simulated moving bed (SMB), a large-scale version of high-performance liquid chromatography (HPLC) used by countless laboratories to purify or separate mixtures of compounds, in the pharmaceutical manufacturing process.
Chiral separation and detection enhancement of propranolol using automated ...
By Varian Inc.
Application note
In this application note, Varian Inc. explains the methodology and the advantages of the liquid chromatography (LC) method for chiral separations and detection enhancement of propranolol by converting enantiomers to diastereomers by precolumn derivatization with optically active reagents.
Industrial chiral chromatography: The key to rapid process development and ...
By Novasep Inc.
White paper
This white paper by Novasep Inc. reviews state-of-the-art chromatographic processes applicable to the production of pure stereoisomers, and describes a method, based on the use of simulation software, to optimize and scale up preparative separations.
Cyclojet preparative HPLC
By Novasep Inc.
Product collateral
Registration is not necessary to view, download or add this product information from Novasep Inc. to My Library.
Varicol multicolumn continuous chromatography
By Novasep Inc.
Product collateral
Registration is not necessary to view, download or add this product information from Novasep Inc. to My Library.
Varicol LAB multicolumn continuous chromatography
By Novasep Inc.
Product collateral
Registration is not necessary to view, download or add this product information from Novasep Inc. to My Library.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
Two-color mutation detection
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes a simple, automated method using a color complementation strategy to detect the most common mutation associated with cystic fibrosis (CF), the three-base pair deletion F508.
Improved method of BAC DNA preparation for sequencing
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, discusses improved methods of preparing bacterial artificial chromosome (BAC) DNA for sequencing by using TempliPhi amplified BAC DNA obtained from minipreps.
Fluorescence quantitation of PCR products using the DyNA Quant 200
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes how the DyNA Quant and DQ130 Capillary Cuvette Kit can be used to determine directly the amount of polymerase chain reaction (PCR) product in an amplification mix.
Analysis of Clontech Atlas Human Cancer cDNA expression macroarrays using the...
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the speed and inherent wide quantitative dynamic range of storage phosphor detection coupled with Storm imaging and ImageQuant analysis, an ideal solution for interpreting Clontech Atlas Human Cancer cDNA expression arrays.
Total RNA purification from cultured cells using the ABI PRISM 6700
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques using the ABI PRISM 6700 Automated Nucleic Acid Workstation that produce high purity total RNA from biological sources such as cultured cells which eliminates the need for post-isolation DNase treatment or other manual handling, and produce a highly pure product, free of PCR inhibitors, that is less prone to...
Real-Time PCR advantages over traditional PCR
By Applied Biosystems
Application note
In this application note, Applied Biosystems discusses the evolution of traditional PCR methods towards the use of Real-Time chemistry and instrumentation for accurate quantitation; and the advantages of real-time PCR over the traditional PCR.
Reconstituting and diluting primers and TaqMan probes
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes the reconstitution of TaqMan lyophilized primers and probes to a working stock concentration which later can be distributed into single-use aliquots to extend their life.
Simultaneous determination of psychotropics in blood using Q TRAP system
By Applied Biosystems
Application note
In this application note, Applied Biosystems discusses its newly developed method using liquid chromatography tandem mass spectrometry for simultaneous determination of psychotropic drugs in human blood using the quadrupole linear ion trap mass spectrometer Q TRAP system.
1-μmol synthesis of DNA using ÄKTA oligopilot plus 10
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the 1-μmol synthesis of DNA using ÄKTA oligopilot plus 10, its process and results.
Labeling sensitivity and dynamic range achievable using the HotScribe ...
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, demonstrates the sensitivity and dynamic range capabilities of the HotScribe First-Strand cDNA Labeling Kit. The kit can be used successfully with phosphate-based hybridization buffers such as Church buffer and more complex buffers such as Denhardt's.
Analysis of Clontech Atlas Human Cancer cDNA expression macroarrays using the...
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the speed and inherent wide quantitative dynamic range of storage phosphor detection coupled with Storm imaging and ImageQuant analysis, an ideal solution for interpreting Clontech Atlas Human Cancer cDNA expression arrays.
DNA analysis using PhastGel homogeneous media
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, summarizes methods that can be used with PhastSystem for the separation of oligonucleotides and double-stranded DNA and the results that can be obtained.
Total RNA purification from cultured cells using the ABI PRISM 6700
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques using the ABI PRISM 6700 Automated Nucleic Acid Workstation that produce high purity total RNA from biological sources such as cultured cells which eliminates the need for post-isolation DNase treatment or other manual handling, and produce a highly pure product, free of PCR inhibitors, that is less prone to...
Reconstituting and diluting primers and TaqMan probes
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes the reconstitution of TaqMan lyophilized primers and probes to a working stock concentration which later can be distributed into single-use aliquots to extend their life.
Total RNA purification from whole blood
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques that produce the highest-quality total RNA from whole blood or isolated blood cells from various animal species and a variety of anticoagulants, including heparin which allows to isolate highly pure, highly stable total RNA directly from whole blood, without sample pre-treatments such as proteinase K...
Storm and PhosphorImager image analysis of cDNA expression macroarrays
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the imaging and analysis of low-density DNA macroarrays with the Storm and PhosphorImager SI systems in order to interpret macro expression arrays.
Tools for use with the ABI 3900 DNA Synthesizer
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes the tools that can be used on the ABI 3900 DNA Synthesizer for the analysis of proteins.
There are currently no reports available for this topic.
Formulation Development
By AAI Pharma Inc.
Product collateral
AAI Pharma's formulation services can help develop solutions; lyophilized injectables; oral liquids; solids formulations of oral capsules; immediate or modified-release tablets; or topicals to meet company needs and that of the marketplace.
International Generic Product Development
By AAI Pharma Inc.
Product collateral
In today’s generic market, time to launch and product pipeline are key determinants to success. AAIPharma's Generic Product Developmentgroup works as a partner throughout the drug development process.
There are currently no reports available for this topic.
Build a better PEGylation team
By Dowpharma
Product collateral
Dowpharma contract manufacturing services focuses on delivering quality activated PEGs with fully characterized functionality and lotto- lot consistency. Dowpharma offers complete PEGylation conjugation services and support to PEGylate protein, peptide, antibody fragment or oligonucleotide.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
ASPEX Rx: Automated microcontamination quality control for drug production
By Aspex Corp.
Product collateral
Aspex presents its ASPEX Rx program for automated microcontamination quality control during drug production and development.
Raman microscopy: An essential aid in characterizing drug delivery products
By Horiba Jobin Yvon
White paper
This white paper by Horiba Jobin Yvon discusses the mapping of creams, timed-release solids and stents using Raman microscopy, which provides hyperspectral cubes from which images can be reconstructed that show distribution, dissolution and molecular associations.
BD BioCoat coverslips
By BD Biosciences
Product collateral
The BD Biooat 35 mm dish with a coverslip bottom is easy to use and facilitates preparation of cells for microscopic analysis. The coverslip floor is Number 1 German glass which is optically clear and non-neurotoxic with low background fluorescence.
Protein mapping of mycoplasmas
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes a method for analyzing cell proteins from ovine and caprine mycoplasmas, or parasites, with two-dimensional (2-D) PAGE, used as a taxonomic tool, in combination with immunoblotting.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
Automated size and intensity trend measurements
By Malvern Instruments Ltd.
Application note
In this application note, Malvern Instruments Ltd. describes its Zetasizer Nano range, which has the capability of automating the measurement of particle size and scattering intensity as a function of temperature or time, and discusses trend measurements options with application examples.
Effect of magnesium stearate on a pharmaceutical blend
By Patheon Inc.
Application note
In this application note, Patheon Inc. describes the influence of the addition of magnesium stearate in a pharmaceutical blend using thermal effusivity, potentially useful in monitoring the progress of lubrication of a blend.
ProteinPilot software for protein identification and expression analysis
By Applied Biosystems
Application note
In this application note, Applied Biosystems explains its ProteinPilot software for performing protein identification and relative protein expression analysis for discovery research.
Simultaneous screen of 23 drugs of abuse by LC-API MS
By Applied Biosystems
Application note
In this application note, Applied Biosystems discusses a LC-MS/MS method with fast scanning which can simultaneously screen 23 drugs of abuse, and present the results in simple format for interpretation by interested parties.
The Buy vs. Build Decision: Decision factors in implementing a Laboratory ...
By GenoLogics Life Sciences Software Inc.
White paper
This White Paper by GenoLogics Life Sciences Software Inc. outlines the key factors to be considered when implementing a LIMS system, with consideration to the overall costs and benefits associated with buying a commercial LIMS system versus building a system in-house.
High-throughput analysis of peptides and proteins
By Agilent Technologies
Application note
In this application note, Agilent Technologies describes the limitations of current protein and peptide analysis technologies and demonstrates the possibilities of high-throughput LC/MS techniques for protein and peptide analysis.
Chromatographic production of human plasma proteins factor VIII, albumin and IgG
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-sciences describes the production, using high-pressure liquid (HPLC) chromatography, of human plasma proteins factor VIII, albumin and IgG.
Reversed-phase preparative and process chromatography
By Grace Davison Discovery Sciences
Application note
In this application note, Grace Vydac, now Grace Davison Discovery Sciences, demonstrates the power of reversed-phase preparative and process chromatography for protein purification.
Histidine-tagged proteins
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Science, formerly Amersham Biosciences describes determination of concentration range of imidazole that minimized the nonspecific binding of untagged proteins to Ni Sepharose high performance, thereby greatly improving target protein purity.
Optimization of the purification of mono-PEG40 avidin
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the purification of mono-PEG40 avidin (mono-poly[ethylene] glycol 40000 avidin) using MacroCap SP cation exchange medium.
Optimizing peptide purifications
By Grace Davison Discovery Sciences
Application note
In this application note, Grace Davison Discovery Sciences, formerly Grace Vydac, shows separations of the same synthetic peptide mixture on two different reversed-phase columns under identical conditions of flow, temperature and organic solvent gradient. The separations show that wide-pore packings provide the best reversed phase separations, among other results.
Total RNA purification from cultured cells using the ABI PRISM 6700
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques using the ABI PRISM 6700 Automated Nucleic Acid Workstation that produce high purity total RNA from biological sources such as cultured cells which eliminates the need for post-isolation DNase treatment or other manual handling, and produce a highly pure product, free of PCR inhibitors, that is less prone to...
Total RNA purification from whole blood
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques that produce the highest-quality total RNA from whole blood or isolated blood cells from various animal species and a variety of anticoagulants, including heparin which allows to isolate highly pure, highly stable total RNA directly from whole blood, without sample pre-treatments such as proteinase K...
Validation of identifications of low abundance proteins using the MIDAS workflow
By Applied Biosystems
Application note
In this application note, Applied Biosystems presents an approach for the validation of low abundance protein identifications using targeted LC/MS/MS experiments on the 4000 Q TRAP LC/MS/MS system.
RediSep C-18 reversed phase column: Purification of carboxylic acids
By Teledyne Isco Inc.
Application note
In this application note, Teledyne Isco, Inc. describes the purification of a mixture of carboxylic acids using Teledyne Isco’s RediSep C-18 reversed phase column as the stationary phase and it illustrates that the use of C-18 reversed phase RediSep column as a highly practical and efficient tool for the purification of carboxylic acids .
Replacing traditional SDS-PAGE and Bradford techniques
By Agilent Technologies
Application note
In this application note, Agilent Technologies describes the purification process of a kinase domain used for crystallization trials and explains how the 5100 Automated Lab-On-A-Chip Platform (ALP) was used to monitor the process. It also compares this with SDS-PAGE and Bradford analysis.
Products before and after EasyPrep purification using the DyNA Quant 200
By Endress + Hauser
Application note
In this application note, Endress & Hauser Inc. describes how its DyNA Quant 200 Fluorometer can quantitate double-stranded polymerase chain reaction (PCR) products prior to purification using the bis-benzimide fluorescence DNA assay, and the materials and the method used.
Multiple mini-format 2-D electrophoresis
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes two-dimensional electrophoresis, a powerful analytical technique to resolve thousands of individual proteins in complex biological samples. The method provides convenience and reproducibility of precast gels for the first and second dimensions.
Protein sequencing of cyanogen bromide digested myoglobin electrotransferred ...
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes methods for analyzing fragments of cyanogen bromide digested sperm whale myoglobin with SDS-PAGE in combination with electrophoretic blotting and direct amino acid sequencing of the blotted peptides.
Spot resolution and detection of proteins in 2-D electrophoresis
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the effects of immobilized gradient (IPG) strip length, protein loading capacity and pH gradient on spot detection and resolution in the second dimension of electrophoresis.
Histidine-tagged proteins
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Science, formerly Amersham Biosciences describes determination of concentration range of imidazole that minimized the nonspecific binding of untagged proteins to Ni Sepharose high performance, thereby greatly improving target protein purity.
Protein mapping of mycoplasmas
By GE Healthcare Bio-Sciences
Application note
In this application note, GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes a method for analyzing cell proteins from ovine and caprine mycoplasmas, or parasites, with two-dimensional (2-D) PAGE, used as a taxonomic tool, in combination with immunoblotting.
High-throughput analysis of peptides and proteins
By Agilent Technologies
Application note
In this application note, Agilent Technologies describes the limitations of current protein and peptide analysis technologies and demonstrates the possibilities of high-throughput LC/MS techniques for protein and peptide analysis.
Real-Time PCR advantages over traditional PCR
By Applied Biosystems
Application note
In this application note, Applied Biosystems discusses the evolution of traditional PCR methods towards the use of Real-Time chemistry and instrumentation for accurate quantitation; and the advantages of real-time PCR over the traditional PCR.
Simultaneous determination of psychotropics in blood using Q TRAP system
By Applied Biosystems
Application note
In this application note, Applied Biosystems discusses its newly developed method using liquid chromatography tandem mass spectrometry for simultaneous determination of psychotropic drugs in human blood using the quadrupole linear ion trap mass spectrometer Q TRAP system.
Validation of identifications of low abundance proteins using the MIDAS workflow
By Applied Biosystems
Application note
In this application note, Applied Biosystems presents an approach for the validation of low abundance protein identifications using targeted LC/MS/MS experiments on the 4000 Q TRAP LC/MS/MS system.
Separation of proteins and peptides by capillary electrophoresis.
By Beckman Coulter Inc.
White paper
This white paper by Beckman Coulter Inc. describes where and why CE can be used as a solution to a critical analytical need and specifically explains the role of capillary electrophoresis in product identity, quantity, purity, heterogeneity, stability, and process consistency is addressed.
Achieve success with biosimulation
By Fluor Corp.
White paper
In this white paper, Fluor Corp. discusses biosimulation and works through the example of improving purification to show the steps involved in using biosimulation for pharmaceutical companies. Process simulation mathematically models a manufacturing process to determine the effects of change.
Life sciences trends and challenges: A technology perspective for 2004-2007
By Hewlett-Packard Co.
White paper
This white paper from HP outlines where technology in the life sciences industry is moving from 2004-2007 and how the industry is adapting to the increasingly quick pace of change.
Characterization of medicinal tablet surface area with the Gemini Series
By Micromeritics Instrument Corp.
White paper
This white paper by Micrometrics Instrument Corp. describes how gas adsorption surface area values can predict the reaction rate of compounds such as medicinal products in tablet or powder form.
Patient device tracking
By SAP Americas Inc.
White paper
This white paper by SAP Labs describes how to integrate customer, physician and patient data to enable compliance and improve customer responsiveness using the mySAP CRM solution, which enables an integrated view of patient device tracking through the enterprise.
Market size in innovation: Theory and evidence from the pharmaceutical industry
By Massachusetts Institute of Technology
White paper
This white paper by MIT develops a simple model linking innovation to potential market size, and shows that under a variety of circumstances, greater market size for a particular product, which implies greater sales, spurs faster innovation.
Level measurement of bulk solids in bins
By Monitor Technologies LLC
White paper
This white paper by Monitor Technologies LLC offers ways to accurately determine level measurement of bulk solids in bins, silos and hoppers.
There are currently no reports available for this topic.
A guide to raw material analysis using fourier transform near-infrared ...
By Thermo Electron Corp.
White paper
This white paper by Thermo Electron Corp. discusses the principles behind the planning, development and implementation of Fourier transform near-infrared (FT-NIR) spectroscopic libraries for raw material identification and qualification and the steps in establishing a raw material program.
Pharmaceutical raw material identification
By Bruker Optics Inc.
White paper
This white paper by Bruker Optics Inc. explains pharmaceutical raw material identification using near-infrared (NIR) spectroscopy.
1-μmol synthesis of DNA using ÄKTA oligopilot plus 10
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, describes the 1-μmol synthesis of DNA using ÄKTA oligopilot plus 10, its process and results.
DNA analysis using PhastGel homogeneous media
By GE Healthcare Bio-Sciences
Application note
This application note by GE Healthcare Bio-Sciences, formerly Amersham Biosciences, summarizes methods that can be used with PhastSystem for the separation of oligonucleotides and double-stranded DNA and the results that can be obtained.
Total RNA purification from cultured cells using the ABI PRISM 6700
By Applied Biosystems
Application note
In this application note, Applied Biosystems describes its newly developed techniques using the ABI PRISM 6700 Automated Nucleic Acid Workstation that produce high purity total RNA from biological sources such as cultured cells which eliminates the need for post-isolation DNase treatment or other manual handling, and produce a highly pure product, free of PCR inhibitors, that is less prone to...
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
There are currently no reports available for this topic.
